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KMID : 0921620150450030272
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Journal of Bacteriology and Virology
2015 Volume.45 No. 3 p.272 ~ p.281
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Immunomodulatory Roles of PE/PPE Proteins and Their Implications in Genomic Features of Mycobacterium tuberculosis
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Choi Soo-Young
Shin Sung-Jae
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Abstract
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Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a notorious cause of human death worldwide. A deeper understanding of the proline-glutamate (PE) and proline-proline-glutamate (PPE) families, which compromise 10% of the coding regions in the Mtb genome, has uncovered their unique roles in host-pathogen interactions. Further, comparative genomic analysis of different Mtb strains has proposed that Mtb has acquired diverse gene sets that play immunomodulatory roles in host-pathogen interactions. This review delineates the various immunomodulatory roles of PE/PPE antigens and discusses their implications in the development of the improved diagnostic tools and vaccines.
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KEYWORD
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Tuberculosis, Mycobacterium tuberculosis, Immunomodulation, PE/PPE protein
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